The potential of Senolytics in transplantation

Tomohisa Matsunaga; Jasper Iske; Andreas Schroeter; Haruhito Azuma; Hao Zhou; Stefan G Tullius

doi:10.1016/j.mad.2021.111582

The potential of Senolytics in transplantation

Mech Ageing Dev. 2021 Dec:200:111582. doi: 10.1016/j.mad.2021.111582. Epub 2021 Oct 1.

Authors

Tomohisa Matsunaga¹, Jasper Iske², Andreas Schroeter³, Haruhito Azuma⁴, Hao Zhou⁵, Stefan G Tullius⁶

Affiliations

¹ Division of Transplant Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Urology, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan.
² Division of Transplant Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Institute of Transplant Immunology, Hannover Medical School, Hannover, Lower Saxony, Germany.
³ Division of Transplant Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Regenerative Medicine and Experimental Surgery, Department of General, Visceral and Transplant Surgery, Hannover Medical School, Hannover, Lower Saxony, Germany.
⁴ Department of Urology, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan.
⁵ Division of Transplant Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
⁶ Division of Transplant Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: stullius@bwh.harvard.edu.

Abstract

Older organs provide a substantial unrealized potential with the capacity to close the gap between demand and supply in organ transplantation. The potential of senolytics in improving age-related conditions has been shown in various experimental studies and early clinical trials. Those encouraging data may also be of relevance for transplantation. As age-differences between donor and recipients are not uncommon, aging may be accelerated in recipients when transplanting older organs; young organs may, at least in theory, have the potential to 'rejuvenate' old recipients. Here, we review the relevance of senescent cells and the effects of senolytics on organ quality, alloimmune responses and outcomes in solid organ transplantation. This article is part of the Special Issue - Senolytics - Edited by Joao Passos and Diana Jurk.

Keywords: Aging; Immunosenescence; Old donors; SASP; Senescent cells; Senolytics; Transplantation.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Aging, Premature / prevention & control
Cellular Senescence / drug effects
Humans
Organ Transplantation / methods*
Senotherapeutics / pharmacology*
Tissue Survival / physiology

Substances

Senotherapeutics

Abstract

Publication types

MeSH terms

Substances

Grants and funding