Resting state predicts neural activity during reward-guided decision making: An fMRI study on Balloon Analogue Risk Task

Claudio Gentili; Elisa Di Rosa; Ioana Podina; Raluca Popita; Bogdan Voinescu; Daniel David

doi:10.1016/j.bbr.2021.113616

Resting state predicts neural activity during reward-guided decision making: An fMRI study on Balloon Analogue Risk Task

Behav Brain Res. 2022 Jan 24:417:113616. doi: 10.1016/j.bbr.2021.113616. Epub 2021 Oct 2.

Authors

Claudio Gentili¹, Elisa Di Rosa², Ioana Podina³, Raluca Popita⁴, Bogdan Voinescu⁵, Daniel David⁶

Affiliations

¹ Department of General Psychology, University of Padua, Padua, Italy.
² Department of General Psychology, University of Padua, Padua, Italy; School of Psychology, Keele University, Staffordshire, UK. Electronic address: elisa.dirosa@unipd.it.
³ Department of Psychology, University of Bucharest, Bucharest, Romania.
⁴ Department of Radiology, The Oncology Institute "Prof. Dr. Ion Chiricuta" (IOCN), Cluj-Napoca, Romania.
⁵ Centre for Academic Mental Health, University of Bristol, Bristol, UK; Department of Clinical Psychology and Psychotherapy, Babeş-Bolyai University, Cluj-Napoca, Romania.
⁶ Department of Clinical Psychology and Psychotherapy, Babeş-Bolyai University, Cluj-Napoca, Romania; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, USA.

PMID: 34606774
DOI: 10.1016/j.bbr.2021.113616

Abstract

In our previous work [8], we have shown that resting state (RS) functional connectivity metrics are significantly related with behavioural performance at Balloon Analogue Risk Task (BART). In the present study we investigated the hypothesis of an association between RS metrics and neural activity evoked by BART execution. A group-level whole-brain regression was run to assess whether RS metrics predict brain activation during the BART, in a sample of 35 young healthy adults (mean age 23 ± 2 years, 25 F). Results complete the previous findings showing that RS is also significantly associated with the neural activity during BART execution. Specifically, ALFF is positively associated with the activity of both the right inferior parietal lobule and the left caudate. These new results are coherent with previous evidence indicating RS abnormalities in clinical conditions characterised by symptoms of impulse control disorders, and further suggest that RS might be a stable predictor of both behavioural indices and neural correlates of impulsivity and of reward-guided decision-making.

Keywords: BART; Impulsivity; Resting state.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Brain / physiology
Caudate Nucleus / metabolism
Decision Making / physiology*
Female
Humans
Impulsive Behavior / physiology*
Magnetic Resonance Imaging*
Male
Parietal Lobe / metabolism
Reward*
Risk-Taking*
Task Performance and Analysis
Young Adult