Highlighting the Relevance of CD8+ T Cells in Filarial Infections

Alexander Kwarteng; Ebenezer Asiedu; Kelvin Kwaku Koranteng; Samuel Opoku Asiedu

doi:10.3389/fimmu.2021.714052

Highlighting the Relevance of CD8⁺ T Cells in Filarial Infections

Front Immunol. 2021 Sep 16:12:714052. doi: 10.3389/fimmu.2021.714052. eCollection 2021.

Authors

Alexander Kwarteng^{1

2}, Ebenezer Asiedu², Kelvin Kwaku Koranteng¹, Samuel Opoku Asiedu^{2

3}

Affiliations

¹ Department of Biochemistry and Biotechnology, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.
² Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Kumasi, Ghana.
³ Department of Theoretical and Applied Biology, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.

Abstract

The T cell immune responses in filarial infections are primarily mediated by CD4⁺ T cells and type 2-associated cytokines. Emerging evidence indicates that CD8⁺ T cell responses are important for anti-filarial immunity, however, could be suppressed in co-infections. This review summarizes what we know so far about the activities of CD8⁺ T cell responses in filarial infections, co-infections, and the associations with the development of filarial pathologies.

Keywords: CD8+; T cell; anti-filarial immunity; filarial co-infections; filarial pathology.

Publication types

Review

MeSH terms

Animals
Biomarkers
CD8-Positive T-Lymphocytes / immunology*
CD8-Positive T-Lymphocytes / metabolism*
Coinfection
Cytokines / metabolism
Disease Models, Animal
Disease Susceptibility / immunology*
Filariasis / etiology*
Filariasis / metabolism*
Filariasis / prevention & control
Host-Parasite Interactions / immunology*
Humans
Immunomodulation
T-Lymphocyte Subsets / immunology*
T-Lymphocyte Subsets / metabolism*
Vaccines / immunology

Substances

Biomarkers
Cytokines
Vaccines