[Formulation Development for the Purpose of Improving Medication Adherence]

Yakugaku Zasshi. 2021;141(10):1173-1184. doi: 10.1248/yakushi.21-00117.
[Article in Japanese]

Abstract

Medication adherence is an important factor in the success or failure of drug treatment. No matter how good a drug is, if a patient cannot or does not want to take it, the therapeutic effect of the drug will not be sufficient and as expected. Therefore, we have been developing formulations with "clinical functionality", namely, formulation characteristics that enhance the likelihood of obtaining the expected therapeutic effect. We researched formulations that are easy to take and deliver expected results; these formulations include gummy drugs as confectionery-like formulations and orally disintegrating (OD) tablets that can be easily swallowed. In particular, OD tablets have been jointly developed with pharmaceutical companies and have been commercialized. Clinical trials with gummy drugs and OD tablets have been conducted to verify the impact of these formulations with clinical functionality on improving medication adherence.

Keywords: clinical functionality; gummi drug; medication adherence; orally disintegrating tablet.

Publication types

  • Review

MeSH terms

  • Administration, Oral
  • Adult
  • Aged
  • Aged, 80 and over
  • Drug Compounding / methods*
  • Drug Compounding / trends
  • Drug Design / methods*
  • Drug Design / trends
  • Female
  • Humans
  • Male
  • Medication Adherence*
  • Tablets
  • Taste
  • Treatment Failure
  • Young Adult

Substances

  • Tablets