Determining the rotational orientation of directional deep brain stimulation electrodes using magnetoencephalography

Mevlüt Yalaz; Günther Deuschl; M Sohail Noor; Markus Butz; Alfons Schnitzler; Ann-Kristin Helmers; Michael Höft

doi:10.1088/1741-2552/ac2c4d

Determining the rotational orientation of directional deep brain stimulation electrodes using magnetoencephalography

J Neural Eng. 2021 Oct 14;18(5). doi: 10.1088/1741-2552/ac2c4d.

Authors

Mevlüt Yalaz¹, Günther Deuschl², M Sohail Noor³, Markus Butz⁴, Alfons Schnitzler⁴, Ann-Kristin Helmers⁵, Michael Höft¹

Affiliations

¹ Chair of Microwave Engineering, Christian-Albrechts-Universität zu Kiel, 24143 Kiel, Germany.
² Department of Neurology, Christian-Albrechts-Universität zu Kiel, 24105 Kiel, Germany.
³ Department of Biomedical Engineering, Duke University, Durham, NC, United States of America.
⁴ Institute of Clinical Neuroscience and Medical iPsychology, Medical Faculty of HHU, 40225 Düsseldorf, Germany.
⁵ Department of Neurosurgery, Christian-Albrechts-Universität zu Kiel, 24105 Kiel, Germany.

PMID: 34598173
DOI: 10.1088/1741-2552/ac2c4d

Abstract

Objective.The aim of the present study was to evaluate the effect of different electrode configurations on the accuracy of determining the rotational orientation of the directional deep brain stimulation (DBS) electrode with our previously published magnetoencephalography (MEG)-based method.Approach.A directional DBS electrode, along with its implantable pulse generator, was integrated into a head phantom and placed within the MEG sensor array. Predefined bipolar electrode configurations, based on activation of different directional and omnidirectional contacts of the electrode, were set to generate a defined magnetic field during stimulation. This magnetic field was then measured with MEG. Finite element modeling and model fitting approach were used to calculate electrode orientation.Main results.The accuracy of electrode orientation detection depended on the electrode configuration: the vertical configuration (activation of two directional contacts arranged one above the other) achieved an average accuracy of only about 41 ^∘. The diagonal configuration (activation of the electrode tip and a single directional contact at the next higher level of the electrode) achieved an accuracy of 13^∘, while the horizontal electrode configuration (activation of two adjacent directional contacts at the same electrode level) achieved the best accuracy of 6^∘. The accuracy of orientation detection of the DBS electrode depends on the change in spatial distribution of the magnetic field with the rotation of the electrode along its own axis. In the vertical configuration, rotation of the electrode has a small effect on the magnetic field distribution, while in the diagonal or horizontal configuration, electrode rotation has a significant effect on the magnetic field distribution.Significance.Our work suggests that in order to determine rotational orientation of a DBS electrode using MEG, horizontal configuration should be used as it provides the most accurate results compared to other possible configurations.

Keywords: SQUID; deep brain stimulation; directional DBS electrode; electrode configuration; magnetic field measurement; magnetoencephalography; rotational orientation detection.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Deep Brain Stimulation*
Electrodes
Magnetoencephalography*
Phantoms, Imaging
Rotation