Antifungal peptides from the marine gorgonian-associated fungus Aspergillus sp. SCSIO41501

Fei-Hua Yao; Xiao Liang; Xia Cheng; Juan Ling; Jun-De Dong; Shu-Hua Qi

doi:10.1016/j.phytochem.2021.112967

Antifungal peptides from the marine gorgonian-associated fungus Aspergillus sp. SCSIO41501

Phytochemistry. 2021 Dec:192:112967. doi: 10.1016/j.phytochem.2021.112967. Epub 2021 Sep 28.

Authors

Fei-Hua Yao¹, Xiao Liang², Xia Cheng¹, Juan Ling², Jun-De Dong², Shu-Hua Qi³

Affiliations

¹ CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou, 510301, Guangdong, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
² CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou, 510301, Guangdong, China.
³ CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou, 510301, Guangdong, China; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou, 511458, China. Electronic address: shuhuaqi@scsio.ac.cn.

PMID: 34598042
DOI: 10.1016/j.phytochem.2021.112967

Abstract

Three undescribed cyclic lipopeptides maribasins C-E and four undescribed linear peptides aspergillipeptides H-K together with three known analogous maribasins A-B and marihysin A were isolated from the marine gorgonian-associated fungus Aspergillus sp. SCSIO 41501 (Trichocomaceae). Their structures were determined by spectroscopic analysis, and their absolute configurations were further confirmed by Marfey's methods. Maribasins C-E and maribasins A-B showed significant antifungal activity against five phytopathogenic fungal strains with MIC values of 3.12-50 μg/disc. Structure-bioactivity relationship exhibited that the β-amino fatty acid chain could significantly affect the antifungal activity of this type of cyclic lipopeptides.

Keywords: Antifungal; Aspergillus sp.; Cyclic lipopeptide; Linear peptide; Marine-derived fungus; Trichocomaceae.

MeSH terms

Antifungal Agents* / pharmacology
Aspergillus*
Fungi
Molecular Structure
Peptides, Cyclic / pharmacology

Substances

Antifungal Agents
Peptides, Cyclic