Successful suppression of musical hallucinations with low-frequency rTMS of the left temporo-parietal junction: A case report

Brain Stimul. 2021 Nov-Dec;14(6):1467-1469. doi: 10.1016/j.brs.2021.09.011. Epub 2021 Sep 28.

Abstract

Background: Inhibitory low frequency repetitive transcranial magnetic stimulation (rTMS) of the temporo-parietal area has been applied to treat both auditory verbal hallucinations as well as tinnitus.

Objective: We hypothesized that 1 Hz rTMS to the left temporoparietal junction (TPJ) may be beneficial in alleviating musical hallucinations (MH), another condition with auditory experiences in the absence of an external source.

Methods: Here we describe a patient with almost insufferable life-long MH with comorbid depression, who received inhibitory rTMS to the left TPJ as well as the right dorsolateral prefrontal cortex (DLPFC).

Results: The intrusiveness and frequency of her MH as well as her depressive symptoms alleviated quickly and substantially, and once-a-week maintenance therapy with rTMS seemed to preserve this amelioration. Future studies will hopefully reveal whether this is a viable treatment approach for other patients suffering from MH with or without comorbid depression.

Keywords: Musical hallucinations; Temporo-parietal junction; rTMS.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Female
  • Hallucinations / therapy
  • Humans
  • Music*
  • Schizophrenia* / therapy
  • Transcranial Magnetic Stimulation / adverse effects
  • Treatment Outcome