The effects of Cl-PFESAs exposure on blood lipids - A community-based large population study in Guangzhou

Xin Mi; Lu-Yin Wu; Jiao-Jiao Liu; Qiu-Ling Fang; Zhengmin Min Qian; Chu Chu; Qing-Qing Li; Fan Su; Yun-Ting Zhang; Peien Zhou; Xiao-Wen Zeng; Hong-Yao Yu; Pengxin Dong; Yang Zhou; Yanqiu Ou; Shimin Xiong; Xubo Shen; Wenru Feng; Yuanzhong Zhou; Guang-Hui Dong

doi:10.1016/j.scitotenv.2021.150634

The effects of Cl-PFESAs exposure on blood lipids - A community-based large population study in Guangzhou

Sci Total Environ. 2022 Feb 1;806(Pt 2):150634. doi: 10.1016/j.scitotenv.2021.150634. Epub 2021 Sep 28.

Authors

Xin Mi¹, Lu-Yin Wu¹, Jiao-Jiao Liu¹, Qiu-Ling Fang¹, Zhengmin Min Qian², Chu Chu¹, Qing-Qing Li¹, Fan Su¹, Yun-Ting Zhang¹, Peien Zhou¹, Xiao-Wen Zeng¹, Hong-Yao Yu¹, Pengxin Dong³, Yang Zhou⁴, Yanqiu Ou⁵, Shimin Xiong⁶, Xubo Shen⁶, Wenru Feng⁷, Yuanzhong Zhou⁸, Guang-Hui Dong⁹

Affiliations

¹ Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
² Department of Epidemiology and Biostatistics, College for Public Health & Social Justice, Saint Louis University, Saint Louis, MO 63104, USA.
³ Nursing College, Guangxi Medical University, Nanning 530021, China.
⁴ State Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment, South China Institute of Environmental Sciences, Ministry of Environmental Protection, Guangzhou 510655, China.
⁵ Department of Epidemiology, Guangdong Cardiovascular Institute, WHO Collaborating Center for Research and Training in Cardiovascular Diseases, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China.
⁶ School of Public Health, Zunyi Medical University, Zunyi 563060, China.
⁷ Department of Environmental Health, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China. Electronic address: gzcdc_fengwr@gz.gov.cn.
⁸ School of Public Health, Zunyi Medical University, Zunyi 563060, China. Electronic address: zhouyuanzhong@163.com.
⁹ Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. Electronic address: donggh5@mail.sysu.edu.cn.

PMID: 34597565
DOI: 10.1016/j.scitotenv.2021.150634

Abstract

Numerous epidemiological studies have investigated the lipid interference effects of legacy PFASs, however, no studies on PFAS alternatives and blood lipids have been published. In this study, we explored the association between Cl-PFESAs, a typical PFASs alternative in China, and blood lipid profiles in 1336 Guangzhou community residents using linear and non-linear regression models. The results showed a deleterious effect of Cl-PFESAs and blood lipids: adjusted estimates (β) for TC, TG, LDL-C and HDL-C per natural log unit increase of 6:2 Cl-PFESA were 0.029 (95% CI: 0.020, 0.038), 0.075 (95% CI: 0.049, 0.101), 0.035 (95% CI: 0.021, 0.049) and -0.071 (95% CI: -0.084, -0.058), respectively. The association between Cl-PFESAs and dyslipidemia was also positively significant (P < 0.05). Furthermore, a non-linear relationship was observed in Cl-PFESAs and serum lipid levels using a restricted cubic splines (RCS) model. In summary, our research suggested a negative impact of Cl-PFESAs on blood lipid patterns and a possible non-linear association.

Keywords: Blood lipids; Cl-PFESAs; PFASs.

MeSH terms

Alkanesulfonic Acids*
China / epidemiology
Fluorocarbons* / analysis
Lipids
Research Design

Substances

Alkanesulfonic Acids
Fluorocarbons
Lipids