Synthesis and Antiprotozoal Profile of 3,4,5-Trisubstituted Isoxazoles

Fernanda Andreia Rosa; Samara Mendes de Souza Melo; Karlos Eduardo Pianoski; Julia Poletto; Mariellen Guilherme Dos Santos; Michael Jackson Vieira da Silva; Danielle Lazarin-Bidóia; Hélito Volpato; Sidnei Moura; Celso Vataru Nakamura

doi:10.1002/open.202100213

Synthesis and Antiprotozoal Profile of 3,4,5-Trisubstituted Isoxazoles

ChemistryOpen. 2021 Oct;10(10):930. doi: 10.1002/open.202100213.

Affiliations

¹ Departamento de Química, Universidade Estadual de Maringá (UEM), Maringá, Brazil.
² Departamento de Ciências Básicas da Saúde, Universidade Estadual de Maringá (UEM), Maringá, Brazil.
³ Instituto de Biotecnologia, Universidade de Caxias do Sul (UCS), Caxias do Sul, Brazil.

Abstract

Invited for this month's cover picture is the group of Prof. Fernanda Andreia Rosa at the State University of Maringá (Brazil). The cover picture shows the contribution of the SINTHET research group to the synthesis and discovery of new antiprotozoal compounds. The synthetic methodology allowed the construction of 60 new isoxazole derivatives with structural variations on the 3-, 4-, and 5-positions. The authors acknowledge Ms. Jeniffer do Nascimento Ascencio Camargo and Ms. Julia Caroline Manzano Willig for the Cover picture creation. Read the full text of their Full Paper at 10.1002/open.202100141.