A Closer Investigation of the Synchronous Bilateral Pattern of MRI Lesions in Acute Necrotizing Encephalopathy Type 1

A Horváthy-Szőcs; Z Liptai; S Dobner; G Rudas; P Barsi

doi:10.3174/ajnr.A7305

A Closer Investigation of the Synchronous Bilateral Pattern of MRI Lesions in Acute Necrotizing Encephalopathy Type 1

AJNR Am J Neuroradiol. 2021 Dec;42(12):2251-2253. doi: 10.3174/ajnr.A7305. Epub 2021 Sep 30.

Authors

A Horváthy-Szőcs¹, Z Liptai^{2

3}, S Dobner^{2

3}, G Rudas⁴, P Barsi⁴

Affiliations

¹ From the Department of Neuroradiology (A.H.-S., G.R., P.B.), Medical Imaging Centre annaszocs@gmail.com.
² Second Department of Pediatrics (Z.L., S.D.), Semmelweis University, Budapest, Hungary.
³ Department of Pediatric Infectology (Z.L., S.D.), St. Laszlo Hospital, Budapest, Hungary.
⁴ From the Department of Neuroradiology (A.H.-S., G.R., P.B.), Medical Imaging Centre.

Abstract

We observed a lesion pattern in a series of 4 cases of RANBP2-mutation-linked acute necrotizing encephalopathy, which appears to be specific for this condition. The setting of synchronous bilateral mammillary, amygdaloid, and lateral geniculate lesions, along with claustro-parahippocampal lesions, can serve as a diagnostic tool in this condition. We add several further details to the MR imaging features of the typical brain lesions encountered in this disease.

MeSH terms

Brain Diseases*
Humans
Leukoencephalitis, Acute Hemorrhagic* / diagnostic imaging
Magnetic Resonance Imaging
Mutation