GABAB receptor signaling in the caudate putamen is involved in binge-like consumption during a high fat diet in mice

Abstract

Previous studies suggest that signaling by the gamma-aminobutyric acid (GABA) type B receptor (GABA_BR) is involved in the regulation of binge eating, a disorder which might contribute to the development of obesity. Here, we show that intermittent access to a high fat diet (HFD) induced binge-like eating behavior with activation of dopamine receptor d1 (drd1)-expressing neurons in the caudate putamen (CPu) and nucleus accumbens (NAc) in wild-type (WT) mice. The activation of drd1-expressing neurons during binge-like eating was substantially increased in the CPu, but not in the NAc, in corticostriatal neuron-specific GABA_BR-deficient knockout (KO) mice compared to WT mice. Treatment with the GABA_BR agonist, baclofen, suppressed binge-like eating behavior in WT mice, but not in KO mice, as reported previously. Baclofen also suppressed the activation of drd1-expressing neurons in the CPu, but not in the NAc, during binge-like eating in WT mice. Thus, our data suggest that GABA_BR signaling in CPu neurons expressing drd1 suppresses binge-like consumption during a HFD in mice.