Validation and modification of the AJCC 8th TNM staging system for pancreatic ductal adenocarcinoma in a Chinese cohort: A nationwide pancreas data center analysis

Hao Hu; Chang Qu; Bingjun Tang; Weikang Liu; Yongsu Ma; Yiran Chen; Xuehai Xie; Yan Zhuang; Hongqiao Gao; Xiaodong Tian; Yinmo Yang

doi:10.21147/j.issn.1000-9604.2021.04.03

Validation and modification of the AJCC 8th TNM staging system for pancreatic ductal adenocarcinoma in a Chinese cohort: A nationwide pancreas data center analysis

Chin J Cancer Res. 2021 Aug 31;33(4):457-469. doi: 10.21147/j.issn.1000-9604.2021.04.03.

Authors

Hao Hu^{1

2}, Chang Qu¹, Bingjun Tang¹, Weikang Liu¹, Yongsu Ma¹, Yiran Chen¹, Xuehai Xie¹, Yan Zhuang¹, Hongqiao Gao¹, Xiaodong Tian¹, Yinmo Yang¹

Affiliations

¹ Department of General Surgery, Peking University First Hospital, Beijing 100034, China.
² Department of Hepatobiliary Surgery, Aerospace Center Hospital, Beijing 100049, China.

PMID: 34584371
PMCID: PMC8435826
DOI: 10.21147/j.issn.1000-9604.2021.04.03

Abstract

Objective: To validate the 8th edition of the American Joint Committee on Cancer (AJCC) staging system for pancreatic ductal adenocarcinoma (PDAC) in a Chinese cohort of radically resected patients and to develop a refined staging system for PDAC.

Methods: Data were collected from the China Pancreas Data Center (CPDC) for patients with resected PDAC in 2016 and 2017, and cancer-specific survival (CSS) was evaluated using the Kaplan-Meier method and log-rank test. Univariate and multivariate analyses based on Cox regression were performed to identify prognostic factors. The recursive partitioning analysis (RPA), Kaplan-Meier method, and log-rank test were performed on the training dataset to generate a proposed modification for the 8th TNM staging system utilizing the preoperative carbohydrate antigen (CA)19-9 level. Validation was performed for both staging systems in the validation cohort.

Results: A total of 1,676 PDAC patients were retrieved, and the median CSS was significantly different between the 8th TNM groupings, with no significant difference in survival between stage IB and IIA. The analysis of T and N stages demonstrated a better prognostic value in the N category. Multivariate analysis showed that the preoperative serum CA19-9 level was the strongest prognostic indicator among all the independent risk factors. All patients with CA19-9 >500 U/mL had similar survival, and we proposed a new staging system by combining IB and IIA and stratifying all patients with high CA19-9 into stage III. The modified staging system had a better performance for predicting CSS than the 8th AJCC staging scheme.

Conclusions: The 8th AJCC staging system for PDAC is suitable for a Chinese cohort of resected patients, and the N category has a better prognostic value than the T category. Our modified staging system has superior accuracy in predicting survival than the 8th AJCC TNM staging system.

Keywords: CA19-9; CPDC; TNM staging; cancer-specific survival; pancreatic ductal adenocarcinoma; prognosis.