On a new piecewise regression model with cure rate: Diagnostics and application to medical data

Abstract

In this article, we discuss an extension of the classical negative binomial cure rate model with piecewise exponential distribution of the time to event for concurrent causes, which enables the modeling of monotonic and non-monotonic hazard functions (ie, the shape of the hazard function is not assumed as in traditional parametric models). This approach produces a flexible cure rate model, depending on the choice of time partition. We discuss local influence on this negative binomial power piecewise exponential model. We report on Monte Carlo simulation studies and application of the model to real melanoma and leukemia datasets.

Keywords: Monte Carlo simulation; binomial negative distribution; cure rate model; leukemia; melanoma; power piecewise exponential distribution.