Evolutionary impact of chimeric RNAs on generating phenotypic plasticity in human cells

Abstract

Chimeric RNAs are generated by the fusion of the exons or introns of two genes. The generation of chimeric RNAs is important for the functional expansion of cells. Here, we describe the functional implications of chimeric RNAs for generating phenotypic plasticity from an evolutionary perspective.

Keywords: cancer evolution; chimeric RNA; gene fusion; phenotypic plasticity.