Potential Antiviral Properties of Industrially Important Marine Algal Polysaccharides and Their Significance in Fighting a Future Viral Pandemic

Viruses. 2021 Sep 13;13(9):1817. doi: 10.3390/v13091817.

Abstract

Over the decades, the world has witnessed diverse virus associated pandemics. The significant inhibitory effects of marine sulfated polysaccharides against SARS-CoV-2 shows its therapeutic potential in future biomedical applications and drug development. Algal polysaccharides exhibited significant role in antimicrobial, antitumor, antioxidative, antiviral, anticoagulant, antihepatotoxic and immunomodulating activities. Owing to their health benefits, the sulfated polysaccharides from marine algae are a great deal of interest globally. Algal polysaccharides such as agar, alginate, carrageenans, porphyran, fucoidan, laminaran and ulvans are investigated for their nutraceutical potential at different stages of infection processes, structural diversity, complexity and mechanism of action. In this review, we focus on the recent antiviral studies of the marine algae-based polysaccharides and their potential towards antiviral medicines.

Keywords: algal polysaccharides; antiviral medicines; marine algae; pandemic; sulfated polysaccharides.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alginates / chemistry
  • Alginates / pharmacology
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology*
  • Aquatic Organisms / chemistry*
  • Glucans / chemistry
  • Glucans / pharmacology
  • Humans
  • Molecular Structure
  • Pandemics
  • Polysaccharides / chemistry
  • Polysaccharides / pharmacology*
  • Seaweed / chemistry*
  • Virus Diseases / drug therapy
  • Virus Diseases / epidemiology*
  • Virus Diseases / etiology
  • Virus Diseases / prevention & control

Substances

  • Alginates
  • Antiviral Agents
  • Glucans
  • Polysaccharides
  • laminaran
  • fucoidan