Interventional Strategies in Cancer-induced Cardiovascular Disease

Curr Oncol Rep. 2021 Sep 27;23(11):133. doi: 10.1007/s11912-021-01113-y.

Abstract

Purpose of review: To highlight the range of illnesses and procedures that the interventional onco-cardiologists face in their daily practice, along with the recent additions to anti-cancer therapies and their related cardiotoxicity.

Recent findings: Immune checkpoint inhibitors (ICI) are not devoid of cardiotoxicity as thought earlier and lead to an increased incidence of myocarditis. Transcatheter valve replacement has been shown to be a safer alternative to surgical replacement in cancer patients. Interventional onco-cardiology is a novel field that addresses cardiovascular diseases in the setting of cancer. Traditionally excluding cancer patients from clinical trials has led to a dearth of information needed to tackle cardiac conditions like Takotsubo cardiomyopathy, malignant pericardial effusions, and radiation-induced vascular diseases encountered either exclusively or predominantly in this high-risk population. This review discusses the various treatment options available in the interventional armamentarium with a particular focus on ICI-myocarditis and transcatheter aortic valve replacement in cancer patients.

Keywords: Acute coronary syndrome; Carcinoid heart disease; Cardio-oncology; Coronary artery disease; Interventional onco-cardiology; Percutaneous coronary intervention; Pericardiocentesis; Takotsubo cardiomyopathy; Transcatheter aortic valve replacement.

Publication types

  • Review

MeSH terms

  • Cardiotoxicity / etiology*
  • Cardiovascular Diseases / etiology*
  • Cardiovascular Diseases / therapy*
  • Humans
  • Immune Checkpoint Inhibitors / adverse effects
  • Myocarditis / chemically induced
  • Neoplasms / complications*
  • Takotsubo Cardiomyopathy / etiology
  • Takotsubo Cardiomyopathy / therapy
  • Transcatheter Aortic Valve Replacement

Substances

  • Immune Checkpoint Inhibitors