Azulene-based fluorescent chemosensor for adenosine diphosphate

Carlos M López-Alled; Sang Jun Park; Dong Joon Lee; Lloyd C Murfin; Gabriele Kociok-Köhn; Jodie L Hann; Jannis Wenk; Tony D James; Hwan Myung Kim; Simon E Lewis

doi:10.1039/d1cc04122c

Azulene-based fluorescent chemosensor for adenosine diphosphate

Chem Commun (Camb). 2021 Oct 12;57(81):10608-10611. doi: 10.1039/d1cc04122c.

Authors

Carlos M López-Alled^{1

2}, Sang Jun Park³, Dong Joon Lee³, Lloyd C Murfin¹, Gabriele Kociok-Köhn⁴, Jodie L Hann¹, Jannis Wenk^{2

5}, Tony D James^{1

2

6}, Hwan Myung Kim³, Simon E Lewis^{1

2}

Affiliations

¹ Department of Chemistry, University of Bath, Bath, BA2 7AY, UK. T.D.James@bath.ac.uk.
² Centre for Sustainable Circular Technologies, University of Bath, Bath, BA2 7AY, UK. J.H.Wenk@bath.ac.uk.
³ Department of Energy Systems Research, Ajou University, Suwon 443-749, South Korea. kimhm@ajou.ac.kr.
⁴ Material and Chemical Characterisation Facility (MC2), University of Bath, Bath, BA2 7AY, UK.
⁵ Department of Chemical Engineering, University of Bath, Bath, BA2 7AY, UK.
⁶ School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, China.

PMID: 34570136
DOI: 10.1039/d1cc04122c

Abstract

AzuFluor® 435-DPA-Zn, an azulene fluorophore bearing two zinc(II)-dipicolylamine receptor motifs, exhibits fluorescence enhancement in the presence of adenosine diphosphate. Selectivity for ADP over ATP, AMP and PPi results from appropriate positioning of the receptor motifs, since an isomeric sensor cannot discriminate between ADP and ATP.

MeSH terms

Adenosine Diphosphate / analysis*
Azulenes / chemistry*
Fluorescent Dyes / chemistry*
Humans
Molecular Structure
Spectrometry, Fluorescence

Substances

Azulenes
Fluorescent Dyes
Adenosine Diphosphate