Immunomodulatory Effect of Irreversible Electroporation Alone and Its Cooperating With Immunotherapy in Pancreatic Cancer

Guo Tian; Jiajia Guan; Yanhua Chu; Qiyu Zhao; Tian'an Jiang

doi:10.3389/fonc.2021.712042

Immunomodulatory Effect of Irreversible Electroporation Alone and Its Cooperating With Immunotherapy in Pancreatic Cancer

Front Oncol. 2021 Sep 10:11:712042. doi: 10.3389/fonc.2021.712042. eCollection 2021.

Authors

Guo Tian^{1

2}, Jiajia Guan¹, Yanhua Chu¹, Qiyu Zhao^{1

2}, Tian'an Jiang^{1

2}

Affiliations

¹ Department of Ultrasound Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
² Department of Biomedicine, Key Laboratory of Pulsed Power Translational Medicine of Zhejiang Province, Hangzhou, China.

Abstract

Emerging studies have showed irreversible electroporation (IRE) focused on pancreatic cancer (PC). However, the effects of IRE treatment on the immune response of PC remain unknown. Moreover, there are few studies on the therapeutic effect of IRE combining with immunotherapy on PC. Thus, we review recent advances in our understanding of IRE alone and its working with immunotherapy towards the immune response of PC, discussing potential opportunities for exploring future treatment strategies.

Keywords: ablation; immunity; immunotherapy; irreversible electroporation; pancreatic cancer.

Publication types

Review