Immune Thrombocytopenia Associated with Hepatitis B Virus and Autoimmune Hepatitis and Recovery of Platelet Count following Liver Transplantation

Chloe Nobuhara; Diana M Cardona; Murat O Arcasoy; Carl L Berg; Andrew S Barbas

doi:10.1155/2021/8484106

Immune Thrombocytopenia Associated with Hepatitis B Virus and Autoimmune Hepatitis and Recovery of Platelet Count following Liver Transplantation

Case Rep Transplant. 2021 Sep 15:2021:8484106. doi: 10.1155/2021/8484106. eCollection 2021.

Authors

Chloe Nobuhara¹, Diana M Cardona², Murat O Arcasoy³, Carl L Berg³, Andrew S Barbas¹

Affiliations

¹ Department of Surgery, Duke University Medical Center, Durham, NC, USA.
² Department of Pathology, Duke University Medical Center, Durham, NC, USA.
³ Department of Medicine, Duke University Medical Center, Durham, NC, USA.

Abstract

Immune thrombocytopenia is a consumptive coagulopathy that can be either idiopathic or associated with infectious or autoimmune etiologies. Here, we present a case of immune thrombocytopenia in the setting of acute liver failure due to coexisting diagnoses of hepatitis B virus and autoimmune hepatitis. Our patient underwent orthotopic liver transplantation and recovered hemostatic platelet counts after treatment with romiplostim, a thrombopoietin receptor agonist, 51 days after transplantation. To our knowledge, this is the first case report of immune thrombocytopenia secondary to both hepatitis B virus and autoimmune hepatitis in a patient with acute liver failure.

Publication types

Case Reports