Regulation and Evasion of Host Immune Response by African Swine Fever Virus

Lei Wu; Bincai Yang; Xu Yuan; Jinxuan Hong; Min Peng; Ji-Long Chen; Zhongbao Song

doi:10.3389/fmicb.2021.698001

Regulation and Evasion of Host Immune Response by African Swine Fever Virus

Front Microbiol. 2021 Sep 8:12:698001. doi: 10.3389/fmicb.2021.698001. eCollection 2021.

Authors

Lei Wu¹, Bincai Yang¹, Xu Yuan¹, Jinxuan Hong¹, Min Peng¹, Ji-Long Chen¹, Zhongbao Song¹

Affiliation

¹ Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou, China.

Abstract

African swine fever (ASF) is an acute lethal hemorrhagic viral disease in domestic pigs and wild boars; is widely epidemic in Africa, Europe, Asia, and Latin America; and poses a huge threat to the pig industry worldwide. ASF is caused by the infection of the ASF virus (ASFV), a cytoplasmic double-stranded DNA virus belonging to the Asfarviridae family. Here, we review how the virus regulates the host immune response and its mechanisms at different levels, including interferon modulation, inflammation, apoptosis, antigen presentation, and cellular immunity.

Keywords: African swine fever virus; apoptosis; immune response; inflammation; interferon; regulation.

Publication types

Review