Effectiveness of aloe vera in patients with type 2 Diabetes Mellitus and pre-diabetes: An overview of systematic reviews

Diabetes Metab Syndr. 2021 Nov-Dec;15(6):102292. doi: 10.1016/j.dsx.2021.102292. Epub 2021 Sep 21.

Abstract

Background and aims: The effects of aloe vera are inconsistent and unclear. The aim of this study is to analyze the effects of aloe vera in metabolic profiles.

Methods: An electronic search of systematic reviews (SRs) was performed in seven databases up to June 2021.

Results: Four SRs met the eligibility criteria. In T2DM, SMD for FBG = -5.61 (p < 0.001). For HbA1c, MD = -0.95 (p = 0.02). In pre-diabetes, SMD for FBG = -1.41 (p = 0.02). For HbA1c, MD = -0.31 (p = 0.02). For TG, MD = -4.99 (p = 0.000).

Conclusion: There exist a moderate to high quality of evidence in favor of the effects of aloe vera in patients with T2DM and pre-diabetes.

Keywords: Aloe vera; Diabetes mellitus; Fasting blood glucose; Overview; Systematic review.

Publication types

  • Systematic Review

MeSH terms

  • Aloe / chemistry*
  • Diabetes Mellitus, Type 2 / drug therapy*
  • Humans
  • Phytotherapy / methods*
  • Plant Extracts / pharmacology*
  • Prediabetic State / drug therapy*

Substances

  • Plant Extracts