Applications of Aptamer-Bound Nanomaterials in Cancer Therapy

Biosensors (Basel). 2021 Sep 18;11(9):344. doi: 10.3390/bios11090344.

Abstract

Cancer is still a major disease that threatens human life. Although traditional cancer treatment methods are widely used, they still have many disadvantages. Aptamers, owing to their small size, low toxicity, good specificity, and excellent biocompatibility, have been widely applied in biomedical areas. Therefore, the combination of nanomaterials with aptamers offers a new method for cancer treatment. First, we briefly introduce the situation of cancer treatment and aptamers. Then, we discuss the application of aptamers in breast cancer treatment, lung cancer treatment, and other cancer treatment methods. Finally, perspectives on challenges and future applications of aptamers in cancer therapy are discussed.

Keywords: aptamers; cancer; nanomaterials; targeting; treatment.

Publication types

  • Review

MeSH terms

  • Aptamers, Nucleotide*
  • Breast Neoplasms / drug therapy*
  • Drug Delivery Systems*
  • Female
  • Humans
  • Nanostructures
  • SELEX Aptamer Technique

Substances

  • Aptamers, Nucleotide