Epigenetic regulation in fibrosis progress

Taixiong Xue; Xingyu Qiu; Hongyao Liu; Cailing Gan; Zui Tan; Yuting Xie; Yuxi Wang; Tinghong Ye

doi:10.1016/j.phrs.2021.105910

Epigenetic regulation in fibrosis progress

Pharmacol Res. 2021 Nov:173:105910. doi: 10.1016/j.phrs.2021.105910. Epub 2021 Sep 22.

Authors

Taixiong Xue¹, Xingyu Qiu¹, Hongyao Liu¹, Cailing Gan¹, Zui Tan¹, Yuting Xie¹, Yuxi Wang², Tinghong Ye³

Affiliations

¹ Sichuan University-University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer, Department of Gastroenterology and Hepatology, Frontiers Science Center for Disease-Related Molecular Network, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
² Sichuan University-University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer, Department of Gastroenterology and Hepatology, Frontiers Science Center for Disease-Related Molecular Network, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China; Targeted Tracer Research and Development Laboratory, Institute of Respiratory Health, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041 Sichuan, China; Precision Medicine Key Laboratory of Sichuan Province & Precision Medicine Research Center, West China Hospital, Sichuan University, Chengdu, 610041 Sichuan, China. Electronic address: yuxiwang@scu.edu.cn.
³ Sichuan University-University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer, Department of Gastroenterology and Hepatology, Frontiers Science Center for Disease-Related Molecular Network, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China. Electronic address: yeth1309@scu.edu.cn.

PMID: 34562602
DOI: 10.1016/j.phrs.2021.105910

Abstract

Fibrosis, a common process of chronic inflammatory diseases, is defined as a repair response disorder when organs undergo continuous damage, ultimately leading to scar formation and functional failure. Around the world, fibrotic diseases cause high mortality, unfortunately, with limited treatment means in clinical practice. With the development and application of deep sequencing technology, comprehensively exploring the epigenetic mechanism in fibrosis has been allowed. Extensive remodeling of epigenetics controlling various cells phenotype and molecular mechanisms involved in fibrogenesis was subsequently verified. In this review, we summarize the regulatory mechanisms of DNA methylation, histone modification, noncoding RNAs (ncRNAs) and N6-methyladenosine (m6A) modification in organ fibrosis, focusing on heart, liver, lung and kidney. Additionally, we emphasize the diversity of epigenetics in the cellular and molecular mechanisms related to fibrosis. Finally, the potential and prospect of targeted therapy for fibrosis based on epigenetic is discussed.

Keywords: DNA methylation; Epigenetic regulation; Fibrosis; Histone modification; N6-methyladenosine modification (m6A); Noncoding RNAs (ncRNAs).

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
DNA Methylation
Epigenesis, Genetic*
Fibrosis / genetics*
Histones / metabolism
Humans
RNA / metabolism

Substances

Histones
RNA