The Prevalence of Elevated Alanine Aminotransferase Levels Meeting Clinical Action Thresholds in Children with Obesity in Primary Care Practice

J Pediatr. 2022 Jan:240:280-283. doi: 10.1016/j.jpeds.2021.09.033. Epub 2021 Sep 23.

Abstract

Using a clinically actionable threshold for alanine aminotransferase to define suspected nonalcoholic fatty liver disease in US children with obesity, the risk of suspected nonalcoholic fatty liver disease was highest for Asian and Hispanic race/ethnicity, male sex, and severe obesity.

Keywords: ALT; NAFLD; alanine aminotransferase; children; ethnicity; nonalcoholic fatty liver disease; obesity; race.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Alanine Transaminase / blood*
  • Biomarkers / blood
  • Child
  • Female
  • Humans
  • Male
  • Non-alcoholic Fatty Liver Disease / blood
  • Non-alcoholic Fatty Liver Disease / diagnosis*
  • Non-alcoholic Fatty Liver Disease / epidemiology
  • Obesity / blood
  • Obesity / epidemiology*
  • Prevalence

Substances

  • Biomarkers
  • Alanine Transaminase