Examining the cooperativity mode of antibody and CD8+ T cell immune responses for vaccinology

Gennady Bocharov; Dmitry Grebennikov; Jordi Argilaguet; Andreas Meyerhans

doi:10.1016/j.it.2021.08.003

Examining the cooperativity mode of antibody and CD8⁺ T cell immune responses for vaccinology

Trends Immunol. 2021 Oct;42(10):852-855. doi: 10.1016/j.it.2021.08.003. Epub 2021 Sep 21.

Authors

Gennady Bocharov¹, Dmitry Grebennikov², Jordi Argilaguet³, Andreas Meyerhans⁴

Affiliations

¹ Marchuk Institute of Numerical Mathematics, Russian Academy of Sciences, 119333 Moscow, Russia; Moscow Center for Fundamental and Applied Mathematics at INM RAS, 119333 Moscow, Russia; Sechenov First Moscow State Medical University, 119991 Moscow, Russia. Electronic address: gbocharov@inm.ras.ru.
² Marchuk Institute of Numerical Mathematics, Russian Academy of Sciences, 119333 Moscow, Russia; Moscow Center for Fundamental and Applied Mathematics at INM RAS, 119333 Moscow, Russia; Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
³ IRTA, Centre de Recerca en Sanitat Animal (IRTA-CReSA), Campus de la Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain.
⁴ Infection Biology Laboratory, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain; ICREA, Pg. Lluís Companys 23, 08010 Barcelona, Spain. Electronic address: andreas.meyerhans@upf.edu.

PMID: 34561159
DOI: 10.1016/j.it.2021.08.003

Abstract

A fundamental unsolved issue in vaccine design is how neutralizing antibodies and cytotoxic CD8⁺ T cells cooperate numerically in controlling virus infections. We hypothesize on a viewpoint for the multiplicative cooperativity between neutralizing antibodies and CD8⁺ T cells and propose how this might be exploited for improving vaccine-induced protective immunity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Neutralizing
Antibodies, Viral
CD8-Positive T-Lymphocytes*
Immunity
Vaccinology*

Substances

Antibodies, Neutralizing
Antibodies, Viral