Epigenetic networks driving T cell identity and plasticity during immunosenescence

Ramon Maria Rodriguez; María Laura Saiz; Beatriz Suarez-Álvarez; Carlos López-Larrea

doi:10.1016/j.tig.2021.08.014

Epigenetic networks driving T cell identity and plasticity during immunosenescence

Trends Genet. 2022 Feb;38(2):120-123. doi: 10.1016/j.tig.2021.08.014. Epub 2021 Sep 21.

Authors

Ramon Maria Rodriguez¹, María Laura Saiz², Beatriz Suarez-Álvarez³, Carlos López-Larrea⁴

Affiliations

¹ Translation Immunology Laboratory, Instituto de Investigación Sanitaria del Principado de Asturias-ISPA, Oviedo, Spain; Red de Investigación Renal (REDinREN), Madrid, Spain; Lipids in Human Pathology, Institut d'Investigació Sanitària Illes Balears (IdISBa, Health Research Institute of the Balearic Islands), Palma, Spain.
² Translation Immunology Laboratory, Instituto de Investigación Sanitaria del Principado de Asturias-ISPA, Oviedo, Spain.
³ Translation Immunology Laboratory, Instituto de Investigación Sanitaria del Principado de Asturias-ISPA, Oviedo, Spain; Red de Investigación Renal (REDinREN), Madrid, Spain. Electronic address: bsuarez@hca.es.
⁴ Translation Immunology Laboratory, Instituto de Investigación Sanitaria del Principado de Asturias-ISPA, Oviedo, Spain; Red de Investigación Renal (REDinREN), Madrid, Spain; Immunology Department, Hospital Universitario Central de Asturias, Oviedo, Spain.

PMID: 34561103
DOI: 10.1016/j.tig.2021.08.014

Abstract

The aging process is associated with the accumulation of epigenetic alterations in immune cells, although the origin of these changes is not clear. Understanding this epigenetic drift in the immune system can provide essential information about the progression of the aging process and the immune history of each individual.

Keywords: T cells; aging; epigenetics; immunosenescence.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Epigenesis, Genetic
Epigenomics
Immunosenescence* / genetics
T-Lymphocytes