A review of topical vitamin C derivatives and their efficacy

J Cosmet Dermatol. 2022 Jun;21(6):2349-2359. doi: 10.1111/jocd.14465. Epub 2021 Sep 24.

Abstract

Vitamin C is a popular ingredient in over-the-counter cosmeceuticals due to its many biological functions in maintaining and improving skin health by treating UV damage, improving discoloration, and boosting collagen production. Several chemically modified derivatives of vitamin C have been developed in an attempt to increase the stability, percutaneous absorption, and overall activity of this ingredient in topical formulations. The goal of this review is to evaluate the differences between vitamin C derivatives that have been designed for cosmeceutical use and their efficacy.

Keywords: anti-aging products; antioxidant; cosmetic chemistry; cosmetic dermatology; topical anti-aging; vitamin C.

Publication types

  • Review

MeSH terms

  • Ascorbic Acid
  • Cosmeceuticals*
  • Humans
  • Skin / metabolism
  • Skin Absorption
  • Skin Aging*
  • Vitamins

Substances

  • Cosmeceuticals
  • Vitamins
  • Ascorbic Acid