A Static Magnetic Field Improves Iron Metabolism and Prevents High-Fat-Diet/Streptozocin-Induced Diabetes

Biao Yu; Juanjuan Liu; Jing Cheng; Lei Zhang; Chao Song; Xiaofei Tian; Yixiang Fan; Yue Lv; Xin Zhang

doi:10.1016/j.xinn.2021.100077

A Static Magnetic Field Improves Iron Metabolism and Prevents High-Fat-Diet/Streptozocin-Induced Diabetes

Innovation (Camb). 2021 Jan 7;2(1):100077. doi: 10.1016/j.xinn.2021.100077. eCollection 2021 Feb 28.

Authors

Biao Yu^{1

2}, Juanjuan Liu³, Jing Cheng³, Lei Zhang¹, Chao Song^{1

2}, Xiaofei Tian^{1

4}, Yixiang Fan^{1

2}, Yue Lv^{1

2}, Xin Zhang^{1

2

4}

Affiliations

¹ High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui 230031, P.R. China.
² Science Island Branch of Graduate School, University of Science and Technology of China, Hefei, Anhui 230036, P.R. China.
³ School of Life Sciences, Anhui University, Hefei, Anhui 230601, P.R. China.
⁴ Institutes of Physical Science and Information Technology, Anhui University, Hefei, Anhui 230601, P.R. China.

Abstract

Type 2 diabetes (T2D) is a metabolic disorder with high prevalence and severe complications that has recently been indicated to be treatable by a combined static magnetic field (SMF) and electric field. We systematically compared four types of SMFs and found that a downward SMF of ∼100 mT could effectively reduce the development of hyperglycemia, fatty liver, weight gain, and tissue injury in high-fat-diet (HFD)/streptozocin-induced T2D mice, but not the upward SMF. The downward SMF markedly restored the Bacteroidetes population and reversed the iron complex outer membrane receptor gene reduction in the mice gut microbiota, and reduced iron deposition in the pancreas. SMF also reduced the labile iron and reactive oxygen species level in pancreatic Min6 cells in vitro and prevented palmitate-induced Min6 cell number reduction. Therefore, this simple SMF setting could partially prevent HFD-induced T2D development and ameliorate related symptoms, which could provide a low-cost and non-invasive physical method to prevent and/or treat T2D in the future.

Keywords: ROS; insulin; iron metabolism; static magnetic field; type 2 diabetes.