Evolution of Cytomegalovirus-Responsive T Cell Clonality following Solid Organ Transplantation

J Immunol. 2021 Oct 15;207(8):2077-2085. doi: 10.4049/jimmunol.2100404. Epub 2021 Sep 22.

Abstract

CMV infection is a significant complication after solid organ transplantation. We used single cell TCR αβ sequencing to determine how memory inflation impacts clonality and diversity of the CMV-responsive CD8 and CD4 T cell repertoire in the first year after transplantation in human subjects. We observed CD8 T cell inflation but no changes in clonal diversity, indicating homeostatic stability in clones. In contrast, the CD4 repertoire was diverse and stable over time, with no evidence of CMV-responsive CD4 T cell expansion. We identified shared CDR3 TCR motifs among patients but no public CMV-specific TCRs. Temporal changes in clonality in response to transplantation and in the absence of detectable viral reactivation suggest changes in the repertoire immediately after transplantation followed by an expansion with stable clonal competition that may mediate protection.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Aged
  • Antigens, Viral / immunology
  • CD4-Positive T-Lymphocytes / immunology*
  • CD8-Positive T-Lymphocytes / immunology*
  • Cell Proliferation
  • Clone Cells
  • Cytomegalovirus / physiology*
  • Cytomegalovirus Infections / immunology*
  • Female
  • Genetic Variation
  • Graft Rejection / immunology*
  • Heart Transplantation*
  • Humans
  • Immunologic Memory
  • Kidney Transplantation*
  • Male
  • Middle Aged
  • Receptors, Antigen, T-Cell, alpha-beta / genetics
  • Transplantation, Homologous
  • Virus Activation / immunology

Substances

  • Antigens, Viral
  • Receptors, Antigen, T-Cell, alpha-beta