Synthesis and antiviral activity of diverse heterocyclic scaffolds

Chem Biol Drug Des. 2022 Dec;100(6):870-920. doi: 10.1111/cbdd.13953. Epub 2021 Oct 7.

Abstract

Heterocyclic moieties form a major part of organic chemistry as they are widely distributed in nature and have wide scale practical applications ranging from extensive clinical use to diverse fields such as medicine, agriculture, photochemistry, biocidal formulations, and polymer science. By virtue of their therapeutic properties, they could be employed in combating many infectious diseases. Among the common infectious diseases, viral infections are of great public health importance worldwide. Thus, there is an urgent need for the discovery and development of antiviral drugs and clinical methods to prevent various viral infections so as to increase the life expectancy. This review presents the comprehensive overview of the synthesis and antiviral activity of different heterocyclic compounds 2015 onwards, which aids in present knowledge and helps the researchers and other stakeholders to explore their field.

Keywords: antiviral; heterocyclic; inhibitors; plant virus; structure-activity relationships.

Publication types

  • Review

MeSH terms

  • Antiviral Agents / chemistry
  • Heterocyclic Compounds* / chemistry
  • Humans
  • Virus Diseases* / drug therapy

Substances

  • Antiviral Agents
  • Heterocyclic Compounds