Discovery Proteomics for COVID-19: Where We Are Now

J Proteome Res. 2021 Oct 1;20(10):4627-4639. doi: 10.1021/acs.jproteome.1c00475. Epub 2021 Sep 22.

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible coronavirus responsible for the pandemic coronavirus disease 2019 (COVID-19), which has had a devastating impact on society. Here, we summarize proteomic research that has helped elucidate hallmark proteins associated with the disease with respect to both short- and long-term diagnosis and prognosis. Additionally, we review the highly variable humoral response associated with COVID-19 and the increased risk of autoimmunity.

Keywords: COVID-19; SARS-CoV-2; biofluids; biomarkers; mass spectrometry; plasma; proteomics.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Autoimmunity
  • COVID-19*
  • Humans
  • Pandemics
  • Proteomics
  • SARS-CoV-2