Disruption of KDM4C-ALDH1A3 feed-forward loop inhibits stemness, tumorigenesis and chemoresistance of gastric cancer stem cells

Signal Transduct Target Ther. 2021 Sep 22;6(1):336. doi: 10.1038/s41392-021-00674-5.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehyde Oxidoreductases / genetics
  • Aldehyde Oxidoreductases / metabolism*
  • Cell Line, Tumor
  • Drug Resistance, Neoplasm*
  • Humans
  • Jumonji Domain-Containing Histone Demethylases / genetics
  • Jumonji Domain-Containing Histone Demethylases / metabolism*
  • Neoplasm Proteins / genetics
  • Neoplasm Proteins / metabolism*
  • Neoplastic Stem Cells / enzymology*
  • Stomach Neoplasms / enzymology*
  • Stomach Neoplasms / genetics

Substances

  • KDM4C protein, human
  • Neoplasm Proteins
  • Jumonji Domain-Containing Histone Demethylases
  • Aldehyde Oxidoreductases
  • aldehyde dehydrogenase (NAD(P)+)