A novel redox cycle diverts cells from oncogene-induced senescence into cancer

Mate Maus; Manuel Serrano

doi:10.1016/j.molcel.2021.08.023

A novel redox cycle diverts cells from oncogene-induced senescence into cancer

Mol Cell. 2021 Sep 16;81(18):3672-3674. doi: 10.1016/j.molcel.2021.08.023.

Authors

Mate Maus¹, Manuel Serrano²

Affiliations

¹ Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona 08028, Spain. Electronic address: mate.maus@irbbarcelona.org.
² Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona 08028, Spain; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona 08010, Spain. Electronic address: manuel.serrano@irbbarcelona.org.

PMID: 34547231
DOI: 10.1016/j.molcel.2021.08.023

Abstract

Igelmann et al. report a novel metabolic cycle, which they name HTC, that converts NADH into the key antioxidant factor NADPH. The HTC is repressed by the tumor suppressors p53 and RB, and this determines whether oncogene-expressing cells undergo senescence (HTC^off) or malignant transformation (HTC^on).

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Cellular Senescence* / genetics
Humans
Neoplasms* / genetics
Oncogenes / genetics
Oxidation-Reduction
Tumor Suppressor Protein p53 / genetics
Tumor Suppressor Protein p53 / metabolism

Substances

Tumor Suppressor Protein p53