Spatiotemporal dynamic regulation of membraneless organelles by chaperone networks

Abstract

Membraneless organelles (MLOs) present as a condensed metastable phase of different proteins and RNAs organized via liquid-liquid phase separation. Recent evidence suggests the extensive incorporation of molecular chaperones into the dynamic assembly of MLOs, where different chaperones coordinate to spatiotemporally maintain the protein homeostasis and avoid abnormal protein aggregation.