Arabinoxylan ameliorates type 2 diabetes by regulating the gut microbiota and metabolites

Qixing Nie; Jielun Hu; Haihong Chen; Fang Geng; Shaoping Nie

doi:10.1016/j.foodchem.2021.131106

Arabinoxylan ameliorates type 2 diabetes by regulating the gut microbiota and metabolites

Food Chem. 2022 Mar 1:371:131106. doi: 10.1016/j.foodchem.2021.131106. Epub 2021 Sep 9.

Authors

Qixing Nie¹, Jielun Hu¹, Haihong Chen¹, Fang Geng², Shaoping Nie³

Affiliations

¹ State Key Laboratory of Food Science and Technology, China-Canada Joint Lab of Food Science and Technology (Nanchang), Nanchang University, Nanchang 330047, China.
² Key Laboratory of Coarse Cereal Processing (Ministry of Agriculture and Rural Affairs), School of Food and Biological Engineering, Chengdu University, Chengdu 610106, China.
³ State Key Laboratory of Food Science and Technology, China-Canada Joint Lab of Food Science and Technology (Nanchang), Nanchang University, Nanchang 330047, China. Electronic address: spnie@ncu.edu.cn.

PMID: 34543925
DOI: 10.1016/j.foodchem.2021.131106

Abstract

Type 2 diabetes (T2D) is a metabolic disease characterized by hyperglycemia. Intake of dietary fiber is inversely associated with risks of T2D. Here, metabolomics and 16S rRNA gene sequencing were employed to investigate the effects of arabinoxylan on gut microbiota and their metabolites in type 2 diabetic rats. T2D increased the abundance of opportunistic pathogens (such as Desulfovibrio and Klebsiella) and the levels of 12α-hydroxylated bile acids and acylcarnitines (C3) in diabetic rats, which eventually contribute to insulin resistance and hyperglycemia. Supplementation with arabinoxylan promoted the growth of fiber-degrading bacteria to increase short-chain fatty acids (SCFAs), as well as decreased the abundance of opportunistic pathogens. Arabinoxylan treatment also decreased the concentrations of 12α-hydroxylated bile acids, and increased the levels of equol, indolepropionate, and eicosadienoic acid. This study indicated that the beneficial effects of arabinoxylan on T2D may be partially attributed to the modification of gut microbiota and related metabolites.

Keywords: Arabinoxylan; Bacteria-derived metabolites; Gut microbiota; Type 2 diabetes.

MeSH terms

Animals
Diabetes Mellitus, Experimental* / drug therapy
Diabetes Mellitus, Experimental* / genetics
Diabetes Mellitus, Type 2* / drug therapy
Diabetes Mellitus, Type 2* / genetics
Gastrointestinal Microbiome*
RNA, Ribosomal, 16S
Rats
Xylans

Substances

RNA, Ribosomal, 16S
Xylans
arabinoxylan