Adrenergic-Thyroid Hormone Interactions Drive Postnatal Thermogenesis and Loss of Mammalian Heart Regenerative Capacity

Alexander Y Payumo; Xi Chen; Kentaro Hirose; Xiaoxin Chen; Alison Hoang; Sheamin Khyeam; Hongyao Yu; Jiajia Wang; Qing Chen; Nevan Powers; Li Chen; Rachel B Bigley; Jonathan Lovas; Guang Hu; Guo N Huang

doi:10.1161/CIRCULATIONAHA.121.054846

Adrenergic-Thyroid Hormone Interactions Drive Postnatal Thermogenesis and Loss of Mammalian Heart Regenerative Capacity

Circulation. 2021 Sep 21;144(12):1000-1003. doi: 10.1161/CIRCULATIONAHA.121.054846. Epub 2021 Sep 20.

Authors

Alexander Y Payumo^#^{1

2

3}, Xi Chen^#^{1

2}, Kentaro Hirose^{1

2}, Xiaoxin Chen^{1

2}, Alison Hoang^{1

2}, Sheamin Khyeam^{1

2}, Hongyao Yu⁴, Jiajia Wang⁴, Qing Chen⁴, Nevan Powers^{1

2}, Li Chen^{1

2}, Rachel B Bigley^{1

2}, Jonathan Lovas^{1

2}, Guang Hu⁴, Guo N Huang^{1

2}

Affiliations

¹ Cardiovascular Research Institute & Department of Physiology (A.Y.P., Xi Chen, K.H., Xiaoxin Chen, A.H., S.K., N.P., L.C., R.B.B., J.L., G.N.H.), University of California, San Francisco.
² Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research (A.Y.P., Xi Chen, K.H., Xiaoxin Chen, A.H., S.K., N.P., L.C., R.B.B., J.L., G.N.H.), University of California, San Francisco.
³ Department of Biological Sciences, San Jose State University, CA (A.Y.P.).
⁴ Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC (H.Y., J.W., Q.C., G.H.).

^# Contributed equally.

No abstract available

Keywords: cell cycle; myocytes, cardiac; receptors, adrenergic; thyroid hormones.

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Animals, Newborn
Heart / physiology*
Mice
Myocytes, Cardiac / metabolism*
Receptors, Adrenergic / metabolism*
Regeneration / physiology*
Thermogenesis / physiology*
Thyroid Hormones / metabolism*

Substances

Receptors, Adrenergic
Thyroid Hormones

Publication types

MeSH terms

Substances

Grants and funding