The State of Microcirculatory Hemodynamics in Patients with Moderate and Severe COVID-19

Bull Exp Biol Med. 2021 Aug;171(4):453-457. doi: 10.1007/s10517-021-05248-7. Epub 2021 Sep 20.

Abstract

Microcirculatory hemodynamic indexes (HI) were assessed in patients with moderate and severe COVID-19. In both groups, a significant increase in the absolute spectral indexes (HI1, HI2, and HI3) and the ratio of low-frequency to high-frequency component (HI1/HI3) was revealed. In the group of severe infection, only the "slow" index (low-frequency HI1) of microcirculatory hemodynamics was significantly lower. The oscillatory indices MAYER1-3 and RESP1-3 were reduced in patients of both groups. The aggravation of the disease course was accompanied by depression of the low-frequency index HI1. Regulatory shifts compensate for disturbances in microcirculatory processes in moderate COVID-19, but severe course was associated with their decompensation.

Keywords: COVID-19; hemodynamic indexes; hemodynamics; microcirculation.

MeSH terms

  • COVID-19 / physiopathology*
  • Hemodynamics / physiology
  • Humans
  • Microcirculation / physiology*