The fabrication of transferrin-modified two-photon gold nanoclusters with near-infrared fluorescence and their application in bioimaging

Kangdi He; Shengrong Yu; Xiao Wang; Dian Li; Jia Chen; Hongmei Zhong; Qing Xu; Yong-Xiang Wu; Ning Gan

doi:10.1039/d1cc03368a

The fabrication of transferrin-modified two-photon gold nanoclusters with near-infrared fluorescence and their application in bioimaging

Chem Commun (Camb). 2021 Oct 7;57(80):10391-10394. doi: 10.1039/d1cc03368a.

Authors

Kangdi He¹, Shengrong Yu^{1

2}, Xiao Wang³, Dian Li¹, Jia Chen¹, Hongmei Zhong¹, Qing Xu¹, Yong-Xiang Wu^{1

2}, Ning Gan¹

Affiliations

¹ State Key Laboratory Base of Novel Functional Materials and Preparation Science, Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis of Zhejiang Province, School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, Zhejiang, 315211, China. yushengrong@nbu.edu.cn.
² Institute of Mass Spectrometry, Ningbo University, Ningbo, Zhejiang 315211, China.
³ Immunology Innovation Team, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, China.

PMID: 34542119
DOI: 10.1039/d1cc03368a

Abstract

Transferrin-modified AuNCs (Tf-AuNCs) with two photon-near infrared (TP-NIR) fluorescence were prepared. For the first time, a novel nanoprobe platform, Tf-AuNCs@MnO₂, was developed for the TP-NIR fluorescence imaging and magnetic resonance imaging of living cells and tissues. This platform had high spatiotemporal resolution and a tissue-penetration depth of 300 μm.

MeSH terms

Fluorescent Dyes / chemistry*
Fluorescent Dyes / radiation effects
Fluorometry
Glutathione / analysis
Glutathione / metabolism
Gold / chemistry
Gold / radiation effects
Humans
Infrared Rays
MCF-7 Cells
Manganese Compounds / chemistry
Metal Nanoparticles / chemistry*
Metal Nanoparticles / radiation effects
Oxides / chemistry
Photons
Transferrin / chemistry*

Substances

Fluorescent Dyes
Manganese Compounds
Oxides
Transferrin
Gold
Glutathione
manganese dioxide