Imaging evaluation of lung cancer treated with PD-1/PD-L1 inhibitors

Br J Radiol. 2021 Nov 1;94(1127):20210228. doi: 10.1259/bjr.20210228. Epub 2021 Sep 19.

Abstract

Immunotherapy (PD-1/PD-L1 inhibitors) has attracted attention for lung cancer treatment and recasted the administration of immunotherapeutics to patients who have advanced/metastatic diseases. Whether in combination or as monotherapy, these medications have become common therapies for certain patients with lung cancer. Moreover, their usage is expected to expand widely in the future. This review aims to discuss the imaging evaluation of lung cancer response to PD-1/PD-L1 therapy with focus on new radiological criteria for immunotherapy response. Abnormal radiological responses (pseudoprogression, dissociative responses, and hyperprogression) and immune-related adverse events are also described.

Publication types

  • Review

MeSH terms

  • Humans
  • Immune Checkpoint Inhibitors / therapeutic use*
  • Immunotherapy / methods*
  • Lung Neoplasms / drug therapy*
  • Programmed Cell Death 1 Receptor / antagonists & inhibitors*

Substances

  • Immune Checkpoint Inhibitors
  • Programmed Cell Death 1 Receptor