Two New Diterpenoids from Biscogniauxia sp. and Their Activities

Huan Zhao; Yue Liu; Meng Zhang; Guo-Dong Chen; Dan Hu; Liang-Dong Guo; Zhong-Xiang Zhao; Hui Zhi; Hao Gao

doi:10.3389/fchem.2021.749272

Two New Diterpenoids from Biscogniauxia sp. and Their Activities

Front Chem. 2021 Sep 1:9:749272. doi: 10.3389/fchem.2021.749272. eCollection 2021.

Authors

Huan Zhao¹, Yue Liu², Meng Zhang², Guo-Dong Chen², Dan Hu², Liang-Dong Guo³, Zhong-Xiang Zhao⁴, Hui Zhi⁴, Hao Gao²

Affiliations

¹ College of Traditional Chinese Medicine, Jinan University, Guangzhou, China.
² Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, China.
³ State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
⁴ School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, China.

Abstract

Two new diterpenoids, including a seco-isopimarane type (1) and an abietane type (2), were isolated from Biscogniauxia sp. (71-10-1-1). Their structures, including absolute configurations, were elucidated by NMR spectroscopic analyses, X-ray crystallography, ¹³C chemical shifts calculations, and ECD calculations. This is the first report of diterpenoids from Biscogniauxia sp. Furthermore, short-term memory enhancement against Alzheimer's disease (AD), anti-inflammatory, and cytotoxic activities of 1-2 were also evaluated. The results showed that compound 1 exhibited short-term memory enhancement activity against AD.

Keywords: Alzheimer’s disease; Biscogniauxia sp; abietane type; diterpenoids; isopimarane type.