Computed Tomography-Based Radiomics Nomogram: Potential to Predict Local Recurrence of Gastric Cancer After Radical Resection

Liebin Huang; Bao Feng; Yueyue Li; Yu Liu; Yehang Chen; Qinxian Chen; Changlin Li; Wensi Huang; Huimin Xue; Xuehua Li; Tao Zhou; Ronggang Li; Wansheng Long; Shi-Ting Feng

doi:10.3389/fonc.2021.638362

Computed Tomography-Based Radiomics Nomogram: Potential to Predict Local Recurrence of Gastric Cancer After Radical Resection

Front Oncol. 2021 Sep 2:11:638362. doi: 10.3389/fonc.2021.638362. eCollection 2021.

Authors

Liebin Huang¹, Bao Feng^{1

2}, Yueyue Li³, Yu Liu², Yehang Chen², Qinxian Chen¹, Changlin Li², Wensi Huang¹, Huimin Xue¹, Xuehua Li⁴, Tao Zhou¹, Ronggang Li⁵, Wansheng Long¹, Shi-Ting Feng⁴

Affiliations

¹ Department of Radiology, Jiangmen Central Hospital, Jiangmen, China.
² School of Electronic Information and Automation, Guilin University of Aerospace Technology, Guilin, China.
³ Department of Radiology, The First Affiliated Hospital of Jinan University, Guangzhou, China.
⁴ Department of Radiology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
⁵ Department of Pathology, Jiangmen Central Hospital, Jiangmen, China.

Abstract

Objective: Accurate prediction of postoperative recurrence risk of gastric cancer (GC) is critical for individualized precision therapy. We aimed to investigate whether a computed tomography (CT)-based radiomics nomogram can be used as a tool for predicting the local recurrence (LR) of GC after radical resection.

Materials and methods: 342 patients (194 in the training cohort, 78 in the internal validation cohort, and 70 in the external validation cohort) with pathologically proven GC from two centers were included. Radiomics features were extracted from the preoperative CT imaging. The clinical model, radiomics signature, and radiomics nomogram, which incorporated the radiomics signature and independent clinical risk factors, were developed and verified. Furthermore, the performance of these three models was assessed by using the area under the curve (AUC) of receiver operating characteristic (ROC) curve analysis and decision curve analysis (DCA).

Results: The radiomics signature, which was comprised of two selected radiomics features, namely, contrast_GLCM and dissimilarity_GLCM, showed better performance than the clinical model in predicting the LR of GC, with AUC values of 0.83 in the training cohort, 0.84 in the internal validation cohort, and 0.73 in the external cohort, respectively. By integrating the independent clinical risk factors (N stage, bile acid duodenogastric reflux and nodular or irregular outer layer of the gastric wall) into the radiomics signature, the radiomics nomogram achieved the highest accuracy in predicting LR, with AUC values of 0.89, 0.89 and 0.80 in the three cohorts, respectively. DCA in the validation cohort showed that radiomics nomogram added more net benefit than the clinical model within the range of 0.01-0.98.

Conclusion: The CT-based radiomics nomogram has the potential to predict the LR of GC after radical resection.

Keywords: computed tomography; gastric cancer; local recurrence (LR); nomogram; radiomics signature.