Molecular epidemiology of hypervirulent Klebsiella pneumoniae: a systematic review and meta-analysis

Rahimeh Sanikhani; Mohammad Moeinirad; Fereshteh Shahcheraghi; Arezou Lari; Sepideh Fereshteh; Amin Sepehr; Afsaneh Salimi; Farzad Badmasti

doi:10.18502/ijm.v13i3.6384

Molecular epidemiology of hypervirulent Klebsiella pneumoniae: a systematic review and meta-analysis

Iran J Microbiol. 2021 Jun;13(3):257-265. doi: 10.18502/ijm.v13i3.6384.

Authors

Rahimeh Sanikhani¹, Mohammad Moeinirad², Fereshteh Shahcheraghi¹, Arezou Lari³, Sepideh Fereshteh¹, Amin Sepehr¹, Afsaneh Salimi¹, Farzad Badmasti¹

Affiliations

¹ Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran.
² Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
³ Department of Systems Biomedicine, Pasteur Institute of Iran, Tehran, Iran.

Abstract

Classical (CKp) and hypervirulent (hvKp) Klebsiella pneumoniae are two different circulating pathotypes. The aim of this study was to assess the prevalence, epidemiology and molecular relatedness of hvKps using a systemic review and meta-analysis. The data extracted from Medline, Embase, and Web of Science and finally 14 studies met the eligible criteria. To combine prevalence proportions of all studies, we performed the metaprop command embedded in the Meta package software. Totally, of 1814 K. pneumoniae isolates, 21.7% (394/1814) were hvKp. The molecular typing showed that all hvKp isolates were grouped into 50 different sequence types (STs) of them ST23, ST11, ST65 and ST86 were common. K1, K2 and K64 were dominant capsule serotypes that strongly related to ST23, ST65 and ST11, respectively. It seems that clonal group 23 (CG23) is associated with liver abscess and CG11 related to various clinical sources.

Keywords: Hypervirulent Klebsiella pneumonia; Molecular typing; Pathotypesi genotypes; Virulence factors.

Publication types

Review