The Effect of Local Renin Angiotensin System in the Common Types of Cancer

Moudhi Almutlaq; Abir Abdullah Alamro; Hassan S Alamri; Amani Ahmed Alghamdi; Tlili Barhoumi

doi:10.3389/fendo.2021.736361

The Effect of Local Renin Angiotensin System in the Common Types of Cancer

Front Endocrinol (Lausanne). 2021 Sep 3:12:736361. doi: 10.3389/fendo.2021.736361. eCollection 2021.

Authors

Moudhi Almutlaq^{1

2}, Abir Abdullah Alamro², Hassan S Alamri^{1

3}, Amani Ahmed Alghamdi², Tlili Barhoumi^{1

3}

Affiliations

¹ King Abdullah International Medical Research Centre, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.
² Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia.
³ Medical Research Core Facility and Platforms, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

Abstract

The Renin Angiotensin System (RAS) is a hormonal system that is responsible for blood pressure hemostasis and electrolyte balance. It is implicated in cancer hallmarks because it is expressed locally in almost all of the body's tissues. In this review, current knowledge on the effect of local RAS in the common types of cancer such as breast, lung, liver, prostate and skin cancer is summarised. The mechanisms by which RAS components could increase or decrease cancer activity are also discussed. In addition to the former, this review explores how the administration of AT1R blockers and ACE inhibitors drugs intervene with cancer therapy and contribute to the outcomes of cancer.

Keywords: ACE inhibitors; AT1R blockers; Ang 1-7; Ang II; Urotensin II; cancer; renin angiotensin system.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Blood Pressure / physiology*
Humans
Neoplasms / physiopathology*
Renin-Angiotensin System / physiology*
Water-Electrolyte Balance / physiology