Herb-Induced Liver Injury Related to Reynoutria multiflora (Thunb.) Moldenke: Risk Factors, Molecular and Mechanistic Specifics

Xing-Ran Zhai; Zheng-Sheng Zou; Jia-Bo Wang; Xiao-He Xiao

doi:10.3389/fphar.2021.738577

Herb-Induced Liver Injury Related to Reynoutria multiflora (Thunb.) Moldenke: Risk Factors, Molecular and Mechanistic Specifics

Front Pharmacol. 2021 Sep 2:12:738577. doi: 10.3389/fphar.2021.738577. eCollection 2021.

Authors

Xing-Ran Zhai¹, Zheng-Sheng Zou^{1

2

3}, Jia-Bo Wang^{3

4}, Xiao-He Xiao^{3

5}

Affiliations

¹ Peking University 302 Clinical Medical School, Beijing, China.
² Medical School of Chinese PLA, Beijing, China.
³ Senior Department of Hepatology, the Fifth Medical Center of PLA General Hospital, Beijing, China.
⁴ School of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
⁵ China Military Institute of Chinese Medicine, the Fifth Medical Center, Chinese PLA General Hospital, Beijing, China.

Abstract

Herbal medicine is widely used in Asia as well as the west. Hepatotoxicity is one of the most severe side effects of herbal medicine which is an increasing concern around the world. Reynoutria multiflora (Thunb.) Moldenke (Polygonum multiflorum Thunb., PM) is the most common herb that can cause herb-induced liver injury (HILI). The recent scientific and technological advancements in clinical and basic research are paving the way for a better understanding of the molecular aspects of PM-related HILI (PM-HILI). This review provides an updated overview of the clinical characteristics, predisposing factors, hepatotoxic components, and molecular mechanisms of PM-HILI. It can also aid in a better understanding of HILI and help in further research on the same.

Keywords: Polygonum multiflorum Thunb.; Reynoutria multiflora (Thunb.) Moldenke; drug-induced liver injury; herb-induced liver injury; molecular mechanisms; predisposing factors.

Publication types

Review