Acute unilateral vision loss and bilateral cerebral infarction following cosmetic filler injection

Orbit. 2023 Apr;42(2):185-188. doi: 10.1080/01676830.2021.1974056. Epub 2021 Sep 20.

Abstract

The current case report describes acute unilateral vision loss and bilateral cerebral infarction as devastating complications following cosmetic injection of hyaluronic acid to the nasal bridge in a 34-year-old female. The patient reported the onset of sudden eye pain, headache, and vision loss in her right eye. At the initial visit to the hospital, the patient had no light perception in the right eye. Examinations revealed marked ptosis and complete ophthalmoplegia with no proptosis. At the time of the patient's hospital evaluation, computed tomography, and magnetic resonance imaging were ordered. Few mottled materials (denser than blood) were observed in the cavernous sinus with a density of 106 Hounsfield units (HU), yet no air was depicted in the cavernous sinus. MRI scan revealed multiple areas of bilateral intracranial infarcts. Although cosmetic injection of hyaluronic acid has been documented as a safe procedure, vision loss remains one of the most feared complications.

Keywords: Cosmetic; filler injection; hyaluronic acid; ophthalmoplegia; vision loss.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Blepharoptosis*
  • Cerebral Infarction / diagnostic imaging
  • Cerebral Infarction / drug therapy
  • Cerebral Infarction / etiology
  • Cosmetic Techniques* / adverse effects
  • Female
  • Humans
  • Hyaluronic Acid / adverse effects
  • Magnetic Resonance Imaging
  • Vision Disorders

Substances

  • Hyaluronic Acid