Blood pressure, frailty and dementia

Jane A H Masoli; João Delgado

doi:10.1016/j.exger.2021.111557

Blood pressure, frailty and dementia

Exp Gerontol. 2021 Nov:155:111557. doi: 10.1016/j.exger.2021.111557. Epub 2021 Sep 17.

Authors

Jane A H Masoli¹, João Delgado²

Affiliations

¹ Epidemiology and Public Health, College of Medicine and Health, University of Exeter, Exeter, UK; Healthcare for Older People Department, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK. Electronic address: j.masoli@exeter.ac.uk.
² Epidemiology and Public Health, College of Medicine and Health, University of Exeter, Exeter, UK.

PMID: 34537278
DOI: 10.1016/j.exger.2021.111557

Abstract

High blood pressure (BP) affects 75% of people aged over 70. Ageing alters BP homeostasis, resulting in postural hypotension and increased BP variability. Co-morbidity and frailty add complexity to understanding BP changes in later life. Longitudinal BP declines are likely driven by accumulating co-morbidity and are accelerated in both frailty and dementia. This narrative review summarises what is known about the association between BP and frailty, the clinical management of BP in frailty and the association between BP, cognitive decline and dementia.

Keywords: Ageing; Blood pressure; Dementia; Frailty; Hypertension.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Aged
Blood Pressure
Dementia* / epidemiology
Frailty*
Humans
Hypertension*
Hypotension, Orthostatic*

Grants and funding

NIHR301445/DH_/Department of Health/United Kingdom