Abstract
This post-hoc analysis evaluated candidate biomarkers of long-term efficacy of subcutaneous interferon beta-1a (sc IFN β-1a) in REFLEX/REFLEXION studies of clinically isolated syndrome. Samples from 507 REFLEX and 287 REFLEXION study participants were analyzed. All investigated biomarkers were significantly upregulated 1.5-4-fold in response to sc IFN β-1a treatment versus baseline (p ≤ 0.008). The validity of MX1, 2'5'OAS, and IL-1RA as biomarkers of response to sc IFN β-1a was confirmed in this large patient cohort, with biomarkers consistently upregulated in a dose-dependent manner. Neopterin, TRAIL, and IP-10 were confirmed as biomarkers associated with long-term sc IFN β-1a treatment efficacy over 5 years.
Keywords:
Biomarkers; Interferon beta; Multiple sclerosis.
Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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2',5'-Oligoadenylate Synthetase / biosynthesis
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2',5'-Oligoadenylate Synthetase / blood
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2',5'-Oligoadenylate Synthetase / genetics
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Biomarkers
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Chemokine CXCL10 / biosynthesis
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Chemokine CXCL10 / blood
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Chemokine CXCL10 / genetics
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Dose-Response Relationship, Drug
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Double-Blind Method
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Follow-Up Studies
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Humans
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Injections, Subcutaneous
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Interferon beta-1a / administration & dosage
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Interferon beta-1a / pharmacokinetics
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Interferon beta-1a / therapeutic use*
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Interleukin 1 Receptor Antagonist Protein / biosynthesis
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Interleukin 1 Receptor Antagonist Protein / blood
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Interleukin 1 Receptor Antagonist Protein / genetics
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Multicenter Studies as Topic
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Multiple Sclerosis / blood
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Multiple Sclerosis / drug therapy*
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Myxovirus Resistance Proteins / biosynthesis
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Myxovirus Resistance Proteins / blood
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Myxovirus Resistance Proteins / genetics
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Neopterin / biosynthesis
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Neopterin / blood
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Neopterin / genetics
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Randomized Controlled Trials as Topic / statistics & numerical data
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TNF-Related Apoptosis-Inducing Ligand / biosynthesis
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TNF-Related Apoptosis-Inducing Ligand / blood
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TNF-Related Apoptosis-Inducing Ligand / genetics
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Up-Regulation
Substances
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Biomarkers
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CXCL10 protein, human
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Chemokine CXCL10
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Interleukin 1 Receptor Antagonist Protein
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MX1 protein, human
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Myxovirus Resistance Proteins
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TNF-Related Apoptosis-Inducing Ligand
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TNFSF10 protein, human
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Neopterin
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2',5'-Oligoadenylate Synthetase
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Interferon beta-1a