Open-source automated insulin delivery systems for the management of type 1 diabetes during pregnancy

Khulood Bukhari; Rana Malek

doi:10.1136/bcr-2021-243522

Open-source automated insulin delivery systems for the management of type 1 diabetes during pregnancy

BMJ Case Rep. 2021 Sep 17;14(9):e243522. doi: 10.1136/bcr-2021-243522.

Authors

Khulood Bukhari¹, Rana Malek²

Affiliations

¹ Department of Medicine, University of Maryland Medical Center Midtown Campus, Baltimore, Maryland, USA khulood.bukhari@gmail.com.
² Department of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Abstract

A 40-year-old woman used an open-source automated insulin delivery system to manage her type 1 diabetes (T1D) prior to conception. The code for building the iPhone application called 'Loop' that carried the software for the hybrid closed-loop controller was available online. Her glycated hemoglobin before conception was 6.4%. Between 6 and 12 weeks gestation, she spent 66% time-in-range (TIR), 28% time-above-range (TAR) and 6% time-below-range (TBR). Between 18 and 24 weeks gestation, she spent 68% TIR, 27% TAR and 5% TBR. During her third trimester, she spent 72% TIR, 21% TAR and 7% TBR. She delivered a healthy infant with no neonatal complications. Clinicians should be aware of this technology as it gains traction in the T1D community and seeks Food and Drug Administration approval.

Keywords: diabetes; endocrinology.

Publication types

Case Reports

MeSH terms

Adult
Blood Glucose
Blood Glucose Self-Monitoring
Diabetes Mellitus, Type 1* / drug therapy
Female
Humans
Infant
Insulin / therapeutic use
Insulin Infusion Systems
Pregnancy

Substances

Blood Glucose
Insulin