Abstract
Paclitaxel (PTX) is successfully loaded by surface modification of distearoyl phosphoethanolamine (DSPE) on halloysite nanotubes (HNTs) with different inner lumen diameters. Drug loading of DSPE-HNTs-PTX attains 18.44% of DSPE content with a nearly complete release (near 100%) achieved. The anticancer efficacy (cell viability less than 52%) of DSPE-HNTs15-PTX increased and is attributed to the lower interfacial energy both inside and outside the tubes that improves tube loading.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology*
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Drug Carriers / chemistry
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Drug Screening Assays, Antitumor
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HT29 Cells
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Humans
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Nanotubes / chemistry*
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Paclitaxel / chemistry
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Paclitaxel / pharmacology*
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Particle Size
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Phosphatidylethanolamines / chemistry*
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Porosity
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Surface Properties
Substances
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Antineoplastic Agents, Phytogenic
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Drug Carriers
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Phosphatidylethanolamines
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1,2-distearoylphosphatidylethanolamine
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Paclitaxel