Surface modified halloysite nanotubes with different lumen diameters as drug carriers for cancer therapy

Chem Commun (Camb). 2021 Sep 16;57(74):9470-9473. doi: 10.1039/d1cc01879e.

Abstract

Paclitaxel (PTX) is successfully loaded by surface modification of distearoyl phosphoethanolamine (DSPE) on halloysite nanotubes (HNTs) with different inner lumen diameters. Drug loading of DSPE-HNTs-PTX attains 18.44% of DSPE content with a nearly complete release (near 100%) achieved. The anticancer efficacy (cell viability less than 52%) of DSPE-HNTs15-PTX increased and is attributed to the lower interfacial energy both inside and outside the tubes that improves tube loading.

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Drug Carriers / chemistry
  • Drug Screening Assays, Antitumor
  • HT29 Cells
  • Humans
  • Nanotubes / chemistry*
  • Paclitaxel / chemistry
  • Paclitaxel / pharmacology*
  • Particle Size
  • Phosphatidylethanolamines / chemistry*
  • Porosity
  • Surface Properties

Substances

  • Antineoplastic Agents, Phytogenic
  • Drug Carriers
  • Phosphatidylethanolamines
  • 1,2-distearoylphosphatidylethanolamine
  • Paclitaxel