Hepatoid adenocarcinoma of the stomach with PIK3Ca mutation during pregnancy: A case report with molecular profile

Anastasija Ranceva; Rokas Stulpinas; Rimvydas Norvilas; Ugnius Mickys

doi:10.1093/omcr/omab078

Hepatoid adenocarcinoma of the stomach with PIK3Ca mutation during pregnancy: A case report with molecular profile

Oxf Med Case Reports. 2021 Sep 13;2021(9):omab078. doi: 10.1093/omcr/omab078. eCollection 2021 Sep.

Authors

Anastasija Ranceva¹, Rokas Stulpinas², Rimvydas Norvilas¹, Ugnius Mickys²

Affiliations

¹ Hematology, Oncology and Transfusion Medicine Center, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.
² National Center of Pathology, Affiliate of Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.

Abstract

Hepatoid adenocarcinoma is an extremely aggressive special subtype of gastric tumors. It can be lethal as no standard treatment options for this type of gastric cancer exist. Here, we describe a very rare case of a young female on her 21^st week of pregnancy who was diagnosed with stage IV hepatoid adenocarcinoma of the stomach with elevated α fetoprotein (AFP) level. Gene mutation analysis performed by next-generation sequencing identified somatic mutations in the PIK3CA gene. Despite the treatment, patient died 2 months after the initial disease presentation. To our best knowledge, this case represents the first report of pregnancy-associated hepatoid gastric adenocarcinoma with the PIK3CA gene mutations, which can provide further clues for the understanding of molecular features of this type of tumor that can reflect biological behavior and may lead to further effective treatment options.

Keywords: PIK3CA, NGS; gastric cancer; hepatoid adenocarcinoma; pregnancy.

Publication types

Case Reports